Page 2 - Dr Stephanie Seneff - Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID - 19
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2021). The sense of urgency around combatting the virus led to the creation, in March 2020, of
               Operation Warp Speed (OWS), then-President Donald Trump’s program to bring a vaccine against
               COVID-19 to market as quickly as possible (Jacobs and Armstrong, 2020).

               OWS established a few more unprecedented aspects of COVID-19. First, it brought the US
               Department of Defense into direct collaboration with US health departments with respect to
               vaccine distribution (Bonsell, 2021). Second, the National Institutes of Health (NIH) collaborated
               with the biotechnology company Moderna in bringing an unprecedented type of vaccine against
               infectious disease to market, one utilizing a technology based on messenger RNA (mRNA)
               (National Institutes of Health, 2020).
               The confluence of these unprecedented events has rapidly brought to public awareness the promise
               and potential of mRNA vaccines as a new weapon against infectious diseases into the future. At the
               same time, events without precedent are, by definition, without a history and context against which
               to fully assess risks, hoped-for benefits, safety, and long-term viability as a positive contribution to
               public health.

               In this paper we will be briefly reviewing one                   Unprecedented
               particular aspect of these unprecedented events,   Many aspects of Covid-19 and subsequent
               namely the development and deployment of          vaccine development are unprecedented for a
               mRNA vaccines against the targeted class of       vaccine deployed for use in the general
               infectious diseases under the umbrella of “SARS-  population. Some of these includes the
               CoV-2.” We believe many of the issues we raise    following.
               here will be applicable to any future mRNA        1.  First to use PEG (polyethylene glycol) in an
               vaccine that might be produced against other          injection (see text)
               infectious agents, or in applications related to   2.  First to use mRNA vaccine technology
               cancer and genetic diseases, while others seem        against an infectious agent
               specifically relevant to mRNA vaccines currently   3.  First time Moderna has brought any product
                                                                     to market
               being implemented against the subclass of corona   4.  First to have public health officials telling
               viruses. While the promises of this technology        those receiving the vaccination to expect an
               have been widely heralded, the objectively            adverse reaction
               assessed risks and safety concerns have received   5.  First to be implemented publicly with
               far less detailed attention. It is our intention to   nothing more than preliminary efficacy data
               review several highly concerning molecular            (see text)
               aspects of infectious disease-related mRNA        6.  First vaccine to make no clear claims about
                                                                     reducing infections, transmissibility, or
               technology, and to correlate these with both          deaths
               documented and potential pathological effects.    7.  First coronavirus vaccine ever attempted in
                                                                     humans
                                                                 8.  First injection of genetically modified
               Vaccine Development                                   polynucleotides in the general population
               Development of mRNA vaccines against
               infectious disease is unprecedented in many ways.
               In a 2018 publication sponsored by the Bill and
               Melinda Gates Foundation, vaccines were divided into three categories: Simple, Complex, and
               Unprecedented (Young et al., 2018). Simple and Complex vaccines represented standard and
               modified applications of existing vaccine technologies. Unprecedented represents a category of
                              International Journal of Vaccine Theory, Practice, and Research 2(1), May 10, 2021 Page | 390
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