Page 15 - Dr Stephanie Seneff - Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID - 19

These important findings need to be emphasized. Antibodies with a high binding affinity to SARS-
CoV-2 spike and other proteins also have a high binding affinity with tTG (associated with Celiac
Disease), TPO (Hashimoto’s thyroiditis), myelin basic protein (multiple sclerosis), and several
endogenous proteins. Unlike the autoimmune process associated with pathogen priming, these
autoimmune diseases typically take years to manifest symptomatically.

The autoantibodies generated by the spike protein predicted by Lyons-Weiler (2020) and described
above were confirmed with an in vitro study published more recently. In this follow-on paper,
Vojdani et. al., (2021) looked again at the issue of cross-reactivity of antibodies, this time using
human monoclonal antibodies (mAbs) against the SARS-CoV-2 spike protein rather than mouse and
rabbit mAbs. Their results confirmed and extended their prior findings. “At a cutoff of 0.32 OD
[optical density], SARS-CoV-2 membrane protein antibody reacted with 18 out of the 55 tested
antigens.” These 18 endogenous antigens encompass reactivity to tissue in liver, mitochondria, the
nervous and digestive system, the pancreas, and elsewhere in the body.

In a report on multisystem inflammatory syndrome in children (MIS-C), Carter et. al. (2020) studied
23 cases. Seventeen of 23 (68%) patients had serological evidence of prior SARS-CoV-2 infection.
Of the three antibodies assessed in the patient population (nucleocapsid, RBD, and spike), IgG spike
protein antibody optical density (which quantifies antibody concentrations against a standardized
curve (Wikipedia, 2021)), was highest (see Figure 1d in Carter et al., 2020).

MIS-C is now commonly speculated to be an example of immune priming by prior exposure to
SARS-CoV-2 or to other coronaviruses. Buonsenso et. al. (2020) reviewed multiple immunologic
similarities between MIS-C and disease related to prior β-hemolytic Group A streptococcal infection
(GAS). The authors write, “We can speculate that children's multiple exposition to SARS-CoV-2
with parents with COVID-19 can work as a priming of the immune system, as happens with GAS
infection and, in genetically predisposed children, lead to [MIS-C] development. Another hypothesis
is that previous infections with other coronaviruses, much more frequent in the pediatric population,
may have primed the child immune system to SARS-CoV-2 virus.”
In June 2019 Galeotti and Bayry (2020) reviewed the occurrence of both autoimmune and
inflammatory diseases in patients with COVID-19. They focus their analysis on MIS-C. After
reviewing several previously published reports of a temporal link between COVID-19 and onset of
MIS-C and describing a number of possible mechanistic connections between the two, the authors
noted that no causal link had been established. In a somewhat prescient recommendation, they
wrote, “A fine analysis of homology between various antigens of SARS-CoV-2 and self-antigens, by
use of in silico approaches and validation in experimental models, should be considered in order to
confirm this hypothesis.” It is precisely this type of in silico analysis carried out by Lyons-Weiler
(2020) and by Ehrenfeld et. al. (2020) described in the opening paragraphs of this section which
found the tight homology between viral antigens and self-antigens. While this may not definitively
confirm the causal link hypothesized by Galeotti and Bayry, it is strong supporting evidence.
Autoimmunity is becoming much more widely recognized as a sequela of COVID-19. There are
multiple reports of previously healthy individuals who developed diseases such as idiopathic
thrombocytopenic purpura, Guillain-Barré syndrome and autoimmune haemolytic anaemia (Galeotti
and Bayry, 2020). There are three independent case reports of systemic lupus erythemosus (SLE)

International Journal of Vaccine Theory, Practice, and Research 2(1), May 10, 2021 Page | 403