Page 29 - Dr Stephanie Seneff - Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID - 19
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may be promoted by well-known Alzheimer’s disease risk factors. The DNA coding for APP is
               reverse transcribed into RNA and then transcribed back into DNA and incorporated into the
               genome at a strand break site. Since RNA is more susceptible to mutations, the DNA in these
               mosaic copies contains many mutant variants of the gene, so the cell becomes a mosaic, capable of
               producing multiple variants of APP. Neurons from Alzheimer's patients contained as many as 500
               million base pairs of excess DNA in their chromosomes (Bushman et al., 2015).

               Researchers from MIT and Harvard published a disturbing paper in 2021, where they provided
               strong evidence that the SARS-CoV-2 RNA can be reverse transcribed into DNA and integrated
               into human DNA (Zhang et al., 2021). They were led to investigate this idea after having observed
               that many patients continue to test positive for COVID-19 after the virus has already been cleared
               from their body. The authors found chimeric transcripts that contained viral DNA sequences fused
               to cellular DNA sequences in patients who had recovered from COVID-19. Since COVID-19 often
               induces a cytokine storm in severe cases, they confirmed the possibility of enhanced reverse
               transcriptase activity through an in vitro study using cytokine-containing conditioned media in cell
               cultures. They found a 2-3-fold upregulation of endogenous LINE-1 expression in response to
               cytokines. The exogenous RNA from the virus incorporated into human DNA could produce
               fragments of viral proteins indefinitely after the infection has been cleared, and this yields a false-
               positive on a PCR test.


                   5.  Bovine Viral Diarrhea: A Disturbing Model
               Bovine Viral Diarrhea (BVD) is an infectious viral disease that affects cattle throughout the world. It
               is a member of the class of pestiviruses, which are small, spherical, single-stranded, enveloped RNA
               viruses. The disease is associated with gastrointestinal, respiratory and reproductive diseases. A
               unique characteristic of BVD is that the virus can cross the placenta of an infected pregnant dam.
               This can result in the birth of a calf which carries intra-cellular viral particles which it mistakes as
               `self.’ Its immune system refuses to recognize the virus as a foreign invasion, and, as a result, the calf
               sheds the virus in large quantities throughout its life, potentially infecting the entire herd. It has
               become a widespread practice to identify such carrier calves and cull them from the herd in an
               attempt to curtail infection (Khodakaram-Tafti & Farjanikish, 2017).
               It seems plausible that a dangerous situation may arise in the future where a woman receives an
               mRNA vaccine for SARS-CoV-2 and then conceives a child shortly thereafter. The sperm would be
               free to take up RNA-embedded liposomes from the vaccine and convert them to DNA using
               LINE-1. They would then produce plasmids containing the code for the spike protein which would
               be taken up by the fertilized egg through the process described above. The infant that is born is then
               potentially unable to mount antibodies to the spike protein because their immune system considers
               it to be `self.’ Should that infant get infected with SARS-CoV-2 at any time in its lifespan, its
               immune system would not mount a defense against the virus, and the virus would presumably be
               free to multiply in the infant’s body without restraint. The infant would logically become a super-
               spreader in such a situation. Admittedly, this is speculation at this time, but there is evidence from
               what we know about retrotransposons, sperm, fertilization, the immune system and viruses, that
               such a scenario cannot be ruled out. It has already been demonstrated in mouse experiments that the
               genetic elements in DNA vector vaccines, which are essentially plasmids, can integrate into the host


                              International Journal of Vaccine Theory, Practice, and Research 2(1), May 10, 2021 Page | 417
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