Page 22 - Dr Stephanie Seneff - Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID - 19

from SARS-CoV-2 to later develop right ventricular heart failure. Furthermore, they suggested that a
similar effect could happen in response to the mRNA vaccines, and they warned of potential long-
term consequences to both children and adults who received COVID-19 vaccines based on the
spike protein (Suzuki and Gychka, 2021).

An interesting study by Lei et. al. (2021) found that pseudovirus — spheres decorated with the
SARS-CoV-2 S1 protein but lacking any viral DNA in their core — caused inflammation and
damage in both the arteries and lungs of mice exposed intratracheally. They then exposed healthy
human endothelial cells to the same pseudovirus particles. Binding of these particles to endothelial
ACE2 receptors led to mitochondrial damage and fragmentation in those endothelial cells, leading to
the characteristic pathological changes in the associated tissue. This study makes it clear that spike
protein alone, unassociated with the rest of the viral genome, is sufficient to cause the endothelial
damage associated with COVID-19. The implications for vaccines intended to cause cells to
manufacture the spike protein are clear and are an obvious cause for concern.

Neurological symptoms associated with COVID-19, such as headache, nausea and dizziness,
encephalitis and fatal brain blood clots are all indicators of damaging viral effects on the brain.
Buzhdygan et al. (2020) proposed that primary human brain microvascular endothelial cells could
cause these symptoms. ACE2 is ubiquitously expressed in the endothelial cells in the brain
capillaries. ACE2 expression is upregulated in the brain vasculature in association with dementia and
hypertension, both of which are risk factors for bad outcomes from COVID-19. In an in vitro study
of the blood-brain barrier, the S1 component of the spike protein promoted loss of barrier integrity,
suggesting that the spike protein acting alone triggers a pro-inflammatory response in brain
endothelial cells, which could explain the neurological consequences of the disease (Buzhdygan et
al., 2020). The implications of this observation are disturbing because the mRNA vaccines induce
synthesis of the spike protein, which could theoretically act in a similar way to harm the brain.

The spike protein generated endogenously by the vaccine could also negatively impact the male
testes, as the ACE2 receptor is highly expressed in Leydig cells in the testes (Verma et al., 2020).
Several studies have now shown that the coronavirus spike protein is able to gain access to cells in
the testes via the ACE2 receptor, and disrupt male reproduction (Navarra et al., 2020; Wang and Xu,
2020). A paper involving postmortem examination of testicles of six male COVID-19 patients found
microscopic evidence of spike protein in interstitial cells in the testes of patients with damaged
testicles (Achua et al., 2021).

A Possible Link to Prion Diseases and Neurodegeneration
Prion diseases are a collection of neurodegenerative diseases that are induced through the misfolding
of important bodily proteins, which form toxic oligomers that eventually precipitate out as fibrils
causing widespread damage to neurons. Stanley Prusiner first coined the name `prion’ to describe
these misfolded proteins (Prusiner, 1982). The best-known prion disease is MADCOW disease
(bovine spongiform encephalopathy), which became an epidemic in European cattle beginning in
the 1980s. The CDC web site on prion diseases states that “prion diseases are usually rapidly
progressive and always fatal.” (Centers for Disease Control and Prevention, 2018). It is now
believed that many neurodegenerative diseases, including Alzheimer’s, Parkinson’s disease, and

International Journal of Vaccine Theory, Practice, and Research 2(1), May 10, 2021 Page | 410